Anxiety Disorders

• Initial: 2-3 mg oral tablet once every 8-12 hours as needed; not to exceed 10 mg/day


• Maintenance: 2-6 mg/day taken orally divided once every 8-12 hours


• Geriatric: Lower initial dose recommended; 1-2 mg orally divided once every 8-12 hours

Short-Term Treatment of Insomnia

• 2-4 mg taken orally at bedtime


• Geriatric: Lower initial dose recommended; 0.5-1 mg orally at bedtime, increase as needed. To avoid over-sedation, the initial daily dose should not exceed 2 mg

Preoperative Sedation, Anxiety Relief, & Anterograde Amnesia

• 0.05 mg/kg intramuscularly (IM) for 1 dose; 2 hours before surgery; not to exceed 4 mg (2 mg in elderly), OR


• 0.044 mg/kg intravenously (IV) for 1 dose; 15-20 minutes before surgery; not to exceed 4 mg (2 mg in elderly)

Status Epilepticus - Adult

• Usual 4 mg/dose slow IV at 2 mg/min


• If seizure persists after 5-10 min, administer 4 mg IV again

Status Epilepticus (Off-label) - Pediatric

• Infants and children: 0.05-0.1 mg/kg IV over 2-5 minutes; not to exceed 4 mg/dose; may repeat every 10-15 minutes as needed


• Alternatively, 0.1 mg/kg at a slow IV rate not to exceed the rate of 2 mg/minute; not to exceed the dose of 4 mg


• Adolescents: 4 mg slow IV; if seizure persists after 10-15 minutes, administer 4 mg IV again

Anxiolytic/Sedation in ICU (Off-label)

• Intubated and mechanically ventilated patients
  
  
  
  • 0.02-0.04 mg/kg IV
  
  
  • 0.02-0.06 mg/kg intermittent IV once every 2-6 hours as needed, OR
  
  
  • 0.01-0.1 mg/kg/hour continuous IV; not to exceed 10 mg/hour
  
  
  
  

Chemotherapy-Induced Nausea/Vomiting (Off-label)

• 0.5-2 mg orally or intravenously (IV) once every 6 hours; as needed thereafter


• Children 2 years and older: 0.025-0.05 mg/kg intravenously (IV) once every 6 hours as needed; not to exceed 2 mg

Chronic Insomnia (Off-label)

• 2-4 mg orally at bedtime.